been selected on the basis of sound scientific judgment. 2008 Dec 1;383(1):18-24. doi: 10.1016/j.ab.2008.08.023. An official website of the United States government. 6-Membered Heterocyclic Compounds [Chemical Structural Class] Tetrahydropyrans [Chemical Structural Class] Monocyclic Tetrahydropyrans [Chemical Structural Class] Epub 2015 Jul 3. shall not be liable for any damage that may result from the Rapid Commun Mass Spectrom. Data Program, but require an annual fee to access. All mass spectra in this site (plus many more) are available from the NIST/EPA/NIH Mass Spectral Library. Pharmacodynamic effects and pharmacokinetics of a new HMG-CoA reductase inhibitor, rosuvastatin, after morning or evening administration in healthy volunteers. Nothing that happens in the labor other workplace is as important as your health and safety. The VWR Traceable Logger-Trac Temperature Datalogger is perfect for monitoring material during storage, handling, and transportation. in general, stereospecificity relations of this sort are examined with the help of other enzyme reactions of known stereospecificity. Optimization, validation and application of an assay for the activity of HMG-CoA reductase. Our solutions, developed with you as our focus, are crafted by our team and network of professionals with advanced degrees in science, quality control, engineering, manufacturing and industry experience. been selected on the basis of sound scientific judgment. Use or mention of technologies or programs in this web site is not Standard Reference Data Act. Wang J, Sun JY, Sha CJ, Shao YF, Liu YH, Li YX, Duan ZW, Liu WH. Mevalonic acid failed to prevent lactacystin-induced . Our portfolio is used in virtually every stage of the most important research, development and production activities in the industries we serve. Bethesda, MD 20894, Web Policies The preparation of compound 8 in seven steps from cyclopentadiene is also described. spectrum (can be printed in landscape orientation). VWR supports you in your autosampler vial selection process through on-site consultations with our Chromatography Specialists, and providing samples when needed. Would you like email updates of new search results? The https:// ensures that you are connecting to the HHS Vulnerability Disclosure, Help [4,4,6,6,6-2H5]Mevalonic Acid Lactone | C6H10O3 | CID 91749840 - structure, chemical names, physical and chemical properties, classification, patents, literature . Data from NIST Standard Reference Database 69: The National Institute of Standards and Technology (NIST) Your session has expired. This deficiency occurs as a result of inherited genetic changes in the MVK gene. The site is secure. Technology, Office of Data Bioanalysis. Data compilation copyright Mevalonic Acid Lactone (4 products available) 1/3. 2002 Nov;54(5):472-7. doi: 10.1046/j.1365-2125.2002.01688.x. dl-Mevalonic acid lactone Formula: C 6 H 10 O 3 Molecular weight: 130.1418 IUPAC Standard InChI: InChI=1S/C6H10O3/c1-6 (8)2-3-9-5 (7)4-6/h8H,2-4H2,1H3 IUPAC Standard InChIKey: JYVXNLLUYHCIIH-UHFFFAOYSA-N CAS Registry Number: 674-26- Chemical structure: This structure is also available as a 2d Mol file These gloves offer the perfect combination of improved elongation with outstanding protection from chemotherapy drugs, and an FDA-approved low dermatitis potential claim. Find . Sesquiterpenes are numbered according to Fig. Unable to load your collection due to an error, Unable to load your delegates due to an error. by the U.S. Secretary of Commerce on behalf of the U.S.A. Technology, Office of Data VWR/Anachemia continues to be the undisputed leader when it comes to supplying laboratories conducting mineral analyses around the world VWR is proud of our years of experience providing choice and excellent service to the Industrial market from Food & Beverage, Petrochemical, Environmental Testing, Waste Water, Cosmetics, Consumer Goods, Agriculture and more See how the unique Nalgene Rapid-Flow membrane support system provides the last line of defense against contamination. VWR is your complete source for workplace supplies. However, NIST makes no warranties to that effect, and NIST High-quality chemicals and services, customized to your product or manufacturing needs VWR enables the advancement of science by providing high-quality chemicals and services, customized to your product or manufacturing needs. jcamp-dx.js and To add items to your cart, enter a quantity and click Add to Cart. 1 it induces depolarization and swelling, decreases nadph content and aconitase (aco) activity, and increases malondialdehyde (mda) production in calcium-loaded rat brain mitochondria. Mevalonic acid terpenes steroids mevalonate biosynthetic Mevalonic acid . 1995 Dec 29;243(2):129-36. doi: 10.1016/0009-8981(95)06162-2. High Quality Dl-Mevalonic Acid Lactone Best Price. Avantor supports end-to-end fluid management solutions including Masterflex peristaltic pumps and aseptic fluid transfer solutions that are reliable and customer-centric, helping bioprocessing manufacturers meet their research and production goals. 2012 Sep;53(9):1987-92. doi: 10.1194/jlr.D028621. uses its best efforts to deliver a high quality copy of the Table 1. Mevalonic acid lactone. Assortment of popular, everyday Nalgene labware in a convenient pack. DL-Mevalonic Acid Lactone, an organic compound in biochemistry, is the primary precursor of isopentenyl pyrophosphate. Ungraded products supplied by Spectrum are indicative of a grade suitable for general industrial use or research purposes and typically are not suitable for human consumption or therapeutic use. Formula: CHO f G : Standard Gibbs free energy of formation (kJ/mol). DL-Mevalonolactone is the -lactone form of mevalonic acid, a precursor in the mevalonate pathway. The products you use, the products you need, the suppliers you trust for chromatography. The incorporation of dl-[2-(14)C]mevalonic acid lactone into beta-carotene and the phytol side chain of chlorophyll has been investigated in cotyledons of four species of pine seedlings (Pinus silvestris, P. contorta, P. radiata and P. jeffrei) grown in darkness and in light. 2002 Jun 25;773(2):103-11. doi: 10.1016/s1570-0232(02)00131-9. been selected on the basis of sound scientific judgment. The interactive spectrum display requires a browser with JavaScript and Compounds identified from GC-MS analysis of EECP-BK. More than 10 major compounds were identified from 2(3H)-Furanone, Oxalic acid - allyl octadecyl ester, dl-mevalonic acid lactone, and arginine has significant pharmacological properties. NIST Standard Reference Our bioprocessing products are engineered to the highest quality standards and regulatory requirements. To compare product details, select up to 3 alternatives below and click Compare Selected. 2003;17(15):1723-34. doi: 10.1002/rcm.1112. jcamp-plot.js. Our global footprint enables us to serve more than 225,000 customer locations and gives us extensive access to research laboratories and scientists in more than 180 countries. FOIA Your institution may already be a subscriber. Exceptional skid resistance, both wet and dry, for dirty jobs and controlled environments. The assay is linear up to 300 ng/ml and has acceptable precision (<15%) and accuracy (<+/-20%) across the calibration range. Avantor supports end-to-end fluid management solutions including peristaltic pumps and aseptic fluid transfer solutions that are reliable and customer-centric, helping bioprocessing manufacturers meet their research and production goals. available from the NIST/EPA/NIH Mass Spectral Library. Easy access to products and protocols for research use only in the identification of 2019-nCoV based on Centers for Disease Control and Prevention (CDC) recommendations. All rights reserved. RT Compounds identified Molecular formula Molecular weight; 1. For your security, we have logged you out. We use operational excellence to deliver solutions that enable research, testing, production, and commercialization across the globe. its accompanying search program. PMC Liquid chromatography/tandem mass spectrometry methods for quantitation of mevalonic acid in human plasma and urine: method validation, demonstration of using a surrogate analyte, and demonstration of unacceptable matrix effect in spite of use of a stable isotope analog internal standard. . Avantor has the resources to make your Chromatography or Mass Spectrometry applications run efficiently and effectivelyfrom the measuring apparatus needed for chromatography, or the proteins used to fulfill sample manipulation during mass spectrometry. 2022 FORTUNE Media IP Limited All rights reserved. ()-Mevalonolactone 97% (titration) sds Safety Information: Preferred SDS: View Hazards identification Classification of the substance or mixture GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) None found. HTML 5 canvas support. Quanta Biosciences and VWR are proud to fund a grant award for publication of research involving qPCR methodologies utilizing any Quanta Bioscience qPCR reagent in JoVE. Contact VWR Custom Manufacturing Services at 1.800.932.5000 or VWRCustom@vwr.com. Epub 2008 Aug 30. Mevalonic acid in urine is converted to its lactone form by incubation overnight at acidic pH, extracted and analysed by GC-MS. Bookshelf View image of digitized You can select and customize services for peak efficiency, quality, and accelerated innovation. Epub 2012 Jun 19. (e.g., Japan AIST/NIMC Database- Spectrum MS-NW-5353. bp Try the improved Chemical Structure search through the new, -Hydroxy-beta-methyl-delta-valerolactone, Life Science Research Solutions, Products, and Resources, Controlled Environment and Cleanroom Solutions, SureSTART Autosampler Vials and Wellplates, Rheo Flexibles: Single Use Containment & Transfer Technology, Thermo Scientific Chromatography Columns and Consumables, Liquid Chromatography - Sample Preparation, Biopharma production chemicals & excipients, Laboratory Personal Protection Equipment (PPE) and Workwear Products, Laboratory Facilities Maintenance, Protection, and Hygiene Supplies, Building a Safe Work Environment with VWR, Aerospace & Automotive Industry Cleanroom Products, Pharmaceuticals, Biotechnology and Nutraceuticals, Micronova - Contamination Control Made Simpler, Quality Products from Sheldon Manufacturing, Agilent Chemistries and Supplies Portfolio, PerkinElmer - Innovating for a Healthier World, Sartorius laboratory instruments, consumables and services, HALO Chromatography Columns and Consumables+-, VWR Returnable Container Advantage Program (ReCAP), The Avantor Value as a Medical Lab Partner, Reference materials Laboratory Products, Specialized Solutions for Cutting Applications, Contact Your Laboratory Furniture Specialist. The carboxylate anion of mevalonic acid, which is the predominant form in biological environments, is known as mevalonate and is of major pharmaceutical importance. Federal government websites often end in .gov or .mil. 2014 Apr;6(7):919-33. doi: 10.4155/bio.13.350. Follow the links above to find out more about the data Avantor Services provides a wide range of specialized services and digital solutions to help you solve complex challenges. on behalf of the United States of America. Twenty-carbon compounds derived from MEVALONIC ACID or deoxyxylulose phosphate. 8600 Rockville Pike The following components were used in generating the plot: Additonal code used was developed at NIST: A strong, vibrant research and development group is the lifeblood of all industries. shall not be liable for any damage that may result from How is savings calculated?We Institute of Standards and Technology, nor is it intended to imply Mevalonic aciduria is caused by deficiency of mevalonate kinase, the first committed enzyme of cholesterol biosynthesis. Br J Clin Pharmacol. total units of the original product. intended to imply recommendation or endorsement by the National Technology, Office of Data 2008 Mar 25;3:45-60. doi: 10.4137/aci.s611. Two procedures are described for the preparation of the racemic mevalonic lactone ()-2, via a meso-dialdehyde 8. the DL-Mevalonic Acid Lactone 18 related questions found. InChI=1S/C6H10O3/c1-6(8)2-3-9-5(7)4-6/h8H,2-4H2,1H3, National Institute of Standards and shall not be liable for any damage that may result from with the development of data collections included in Freeze cells in tubes from 1 to 5mL using the Thermo Scientific Mr. Frosty Freezing Container at nearly -1C/minute. HTML 5 canvas support. Avantor can help you plan, design, and configure a custom laboratory environment that meets all your needs. Ungraded products supplied by Spectrum are indicative of a grade suitable for general industrial use or research purposes and typically are not suitable for human consumption or therapeutic use. Before Notice: This spectrum may be better viewed with a Javascript Notice: This spectrum may be better viewed with a Javascript Go To: Top, Mass spectrum (electron ionization), Notes, Go To: Top, Mass spectrum (electron ionization), References. $256.00 / kilogram. IUPAC Standard InChIKey: JYVXNLLUYHCIIH-UHFFFAOYSA-N Copy CAS Registry Number: 674-26- Chemical structure: This structure is also available as a 2d Mol file; Other . on behalf of the United States of America. Disclaimer, National Library of Medicine Data from NIST Standard Reference Database 69: The National Institute of Standards and Technology (NIST) Determination of key intermediates in cholesterol and bile acid biosynthesis by stable isotope dilution mass spectrometry. The lower limit of quantitation of 7.5 ng/ml provides adequate sensitivity to measure changes in urinary excretion of MVA following administration of drugs which affect cholesterol synthesis. What Makes an Aroma? 2. 1 kilogram (Min Order) CN. and Informatics, NIST / TRC Web Thermo Tables, professional edition (thermophysical and thermochemical data), NIST Mass Spectrometry Data Center, William E. Wallace, director, Modified by NIST for use in this application. For more information, call 1.888.793.2300 or email us at services@avantorsciences.com. Don't miss out, order yours today! A sensitive and selective method for the determination of mevalonic acid in dog plasma by gas chromatography/negative ion chemical ionization-mass spectrometry. click the mouse on the plot to revert to the orginal display. on behalf of the United States of America. click the mouse on the plot to revert to the orginal display. ,-Hydroxy-beta-methyl-delta-valerolactone Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for We found alternative products that can save you up to per item-unit. 2002. ,()-Mevalonolactone official website and that any information you provide is encrypted NIST Standard Reference jcamp-dx.js and However, NIST makes no warranties to that effect, and NIST 2021 by the U.S. Secretary of Commerce Data compiled by: NIST Mass Spectrometry Data Center, William E. Wallace, director. The purpose of the fee is to recover costs associated Mevalonic acid ( MVA) is a key organic compound in biochemistry; the name is a contraction of dihydroxymethylvalerolactone. Copyright for NIST Standard Reference Data is governed by The interactive spectrum display requires a browser with JavaScript and Avantor carries a broad range of trusted products to help you meet the needs of your lab applications and protocols. Dehydromevalonic lactone Formula: C 6 H 8 O 2 Molecular weight: 112.1265 IUPAC Standard InChI: InChI=1S/C6H8O2/c1-5-2-3-8-6 (7)4-5/h4H,2-3H2,1H3 IUPAC Standard InChIKey: RPEASMBMVIKUTH-UHFFFAOYSA-N CAS Registry Number: 2381-87-5 Chemical structure: This structure is also available as a 2d Mol file or as a computed 3d SD file VAI's cellulose free, low particlate and chemical resistant cleanroom paper. key features of this work include the creation of a total biosynthetic route to produce mvl, an efficient semisynthetic approach that employs high-yielding chemical reactions to transform mevalonate to mvl, and the use of controlled polymerization techniques to produce well-defined pla-pmvl-pla triblock polymers, where pla stands for poly MeSH J Pharm Anal. Precautionary statement(s) Mevalonic acid lactone by itself did not affect the viability of differentiated NB cells or the proteasome activity, but it completely prevented mevastatin-induced degeneration and decreased viability by reducing the uptake of mevastatin and by blocking its action on proteasome activity. We continue to set science in motion to create a better world by providing you with the right solutions to keep moving forward. The lower limit of quantitation of 7.5 ng/ml provides adequate sensitivity to measure changes in urinary excretion of MVA following administration of drugs which affect cholesterol synthesis. Avantor helps keep you safe with a robust line of safety products and personal protective equipment -- from waste bins to safety signs. Yoshida T, Honda A, Miyazaki H, Matsuzaki Y. Anal Chem Insights. Quantification of urinary mevalonic acid as a biomarker of HMG-CoA reductase activity by a novel translational LC-MS/MS method. Matsuoka T, Ueda S, Matsumoto H, Kawakami M. J Lipid Res. Durable, low-linting, & available in white or blue. Database and to verify that the data contained therein have with the development of data collections included in GHS Label elements, including precautionary statements Pictogram Hazard statement(s) None found. Data compilation copyright Simagchem Corp. Select a region with data to zoom. Data Program, but require an annual fee to access. Anal Biochem. such sites. Images of the chemical structure of DL-Mevalonic acid lactone are given below: This procedure intends to be model for a desymmetrization study of dialdehyde 8, leading to optically active (-) (R)- and (+) (S . Data compiled by: NIST Mass Spectrometry Data Center, William E. Wallace, director. 2015 Dec;5(6):383-388. doi: 10.1016/j.jpha.2015.06.002. These goggles are comfortable and have good peripheral vision. Select a region with no data or Notice: Concentration information is not available for this spectrum and, therefore, molar absorptivity values cannot be derived. Please enable it to take advantage of the complete set of features! Select a region with data to zoom. the Avantor can help maintain cleanroom standards with protective apparel and environmental monitoring equipment. that these items are necessarily the best available for the purpose. NIST subscription sites provide data under the ,Tetrahydro-4-hydroxy-4-methyl-2-pyrone. jcamp-plot.js. All rights reserved. As our customers needs have evolved, so have our capabilities. Additional Data Mevalonic acid in urine is converted to its lactone form by incubation overnight at acidic pH, extracted and analysed by GC-MS. The DL-Mevalonic acid lactone molecule contains a total of 19 bond(s) There are 9 non-H bond(s), 1 multiple bond(s), 1 double bond(s), 1 six-membered ring(s), 1 ester(s) (aliphatic), 1 hydroxyl group(s) and 1 tertiary alcohol(s). As your trusted, collaborative partner, Avantor Services helps you increase efficiency, maximize productivity, and accelerate innovation. Fog-free, soft sided, and splash resistant. VWR's cell culture portfolio provides all the essential instruments, tailored to the needs of your cell biology processes. The relative inco [5,5-2 H 2]-Mevalonic acid lactone (A) or [5,5-2 H 2]-1-deoxy-D-xylulose (B) were used as precursors incorporated via the MVA and DOXP/MEP pathways, respectively. We set science in motion to create a better world. All rights reserved. Mevalonic lactone, DELTA2-anhydro-2,3-Anhydromevalonic acid delta-lactone; 2-Pentenoic acid, 5-hydroxy-3-methyl-, lactone; 5,6-Dihydro-4-methyl-(2H)-pyran-2-one, dehydromevalonic acid lactone; C p,gas: Ideal gas heat capacity (J/molK). 3.08: Available in 8.5x11, A4, pre-hole punched and multiple colors. government site. 1. uses its best efforts to deliver a high quality copy of the Rodrigues AV, Maggs JL, McWilliam SJ, Pirmohamed M, Coen M, Wilson ID, Park BK, Antoine DJ. Dependable -80C storage with a focus on sustainability without sacrificing sample protection. Avantor, a Fortune 500 company, is a leading global provider of mission-critical products and services to customers in the biopharma, healthcare, education & government, and advanced technologies & applied materials industries. Database and to verify that the data contained therein have and transmitted securely. 1.) Your institution may already be a subscriber. The lower limit of qua Used under license. 2021 by the U.S. Secretary of Commerce Binders, calendars, pens, cleaning and sanitation supplies, and office equipment are just some of the essential products we offer Science education supplies, specimens, activities, and equipment for all grade levels kindergarten to college. All rights reserved. InChI=1S/C6H10O3/c1-6(8)2-3-9-5(7)4-6/h8H,2-4H2,1H3, National Institute of Standards and In addition to vwr.com, VWR, part of Avantor offers a state-of-the-art technology solutions portfolio. Full details of a high yielding synthesis of mevalonic acid lactone (1) which is of particular value in the preparation of 3- and/or 3-labelled compounds are described.The key step, conversion of 3-hydroxy-3-methylpentane-1,5-dioic acid (3) into 3-hydroxy-3-methylpentane-1,5-dioic anhydride (4) using acetic anhydride, has been fully investigated, and an additional method using acetyl . Avantor can help equip your life sciences lab with the products, equipment, and supplies you need whether you work in cell biology, genomics, proteomics, or other fields. Chemicals by Class. 5 year bumper to bumper warranty! Weve built our reputation on consistent, comprehensive mastery of day-to-day operations, allowing lab, clinical, and production environments to focus their high-value resources on core scientific priorities. However, NIST makes no warranties to that effect, and NIST Siavoshian S, Simoneau C, Maugeais P, Marks L, Rodary L, Gardette J, Krempf M. Clin Chim Acta. errors or omissions in the Database. Database and to verify that the data contained therein have Lactone Monomers, Lactide Monomers. 1.) Properties 97% n20/D 1.473 (lit.) Select a region with no data or The following components were used in generating the plot: Additonal code used was developed at NIST: and HTML 5 enabled browser. uses its best efforts to deliver a high quality copy of the J Pharm Biomed Anal. For information visit, www.avantorsciences.com and find us on LinkedIn, Twitter and Facebook. Explore our solutions for multiple applications - vaccines, monoclonal antibodies, recombinant proteins, cell or gene therapy. in these sites and their terms of usage. InChI=1S/C6H10O3/c1-6(8)2-3-9-5(7)4-6/h8H,2-4H2,1H3, National Institute of Standards and Cleanrooms or other controlled environments used for research or manufacturing need specialized products. by the U.S. Secretary of Commerce on behalf of the U.S.A. Detection of nonsterol isoprenoids by HPLC-MS/MS. Please see the following for information about the library and its accompanying search program. Our product offerings can help with biomedical research, forensic work, and clinical diagnostics. errors or omissions in the Database. and Informatics, NIST / TRC Web Thermo Tables, professional edition (thermophysical and thermochemical data). multiply the savings per unit (in parenthesis) times the This IR spectrum is from the Mevalonic acid in urine is converted to its lactone form by incubation overnight at acidic pH, extracted and analysed by GC-MS.

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