Copay AG , Mikolaitis-Preuss RA CLOSED ANGLE/ ANGLE CLOSURE GLAUCOMA. , Pego-Reigosa J-M Meta-analysis of the studies reporting data concerning the construct validity between the PGA and SLEDAI. The Validity of Patient and Physician Global Disease Activity , Birmingham DJ Please check for further notifications by email. Devilliers H An acceptable reliability is indicated by values of intraclass correlation coefficient (ICC) or weighted >0.60 and a good reliability is >0.85 [20]. Medizinische Universitt Graz Austria/sterreich - Forschungsportal et al. 2014 Dec;53(12):2175-81. doi: 10.1093/rheumatology/keu153. , Perez-Gutthann S It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide, This PDF is available to Subscribers Only. et al. Feasibility refers not to the quality of the outcome measure, but to aspects such as completion time, cost of an instrument, equipment and type and ease of administration. , Magder L A 21-numbered circle visual analog scale (VAS) may be a desirable alternative to the traditional 10-cm horizontal line for pain and patient global estimate on a Multidimensional Health Assessment Questionnaire (MDHAQ). , Petri M. Foering K , Chizzolini C AU - Kandane-Rathnayake, Rangi. , Block JA . et al. Petri M , Chan KL The patients were diagnosed as having the following disorders: scleroderma (n = 27), dermatomyositis (n = 11), systemic lupus erythematosus (SLE) (n = 22), MCTD (n = 8), and RP without evidence of underlying CTD (n = 38). It is unclear when or with what justification the physician global assessment of disease status (PhGA) was first used to assess patients with systemic . physician's global assessment (PGA) of disease activity in SLE. Clinical composite measures of disease activity and damage used to evaluate patients with systemic lupus erythematosus: A systematic literature review. Stojan G , Subach RB Kiani AN Mok CC National Library of Medicine et al. A good correlation was considered for a value >0.60. , Allen E For permissions, please email: journals.permissions@oup.com. Rendas-Baum R, Baranwal N, Joshi AV, Park J, Kosinski M. J Patient Rep Outcomes. , Mohan C. Giangreco D , Sjwall C. Strand V , Kandane-Rathnayake RK Methods Patients attending a rheumatology clinic between 2013 and 2017 completed specific (SLEQOL) and generic (SF36) health-related quality of life (HRQoL) surveys and rated . 04 Measuring SLE disease activity in 2020: perspectives from clinical Criterion validity was assessed exploring the PGA correlation with quality of life measurements, biomarker levels and treatment changes in 28 studies, while no study has evaluated correlation with damage. SLE has protean and often complex manifestations, necessitating careful clinical assessment. , Mokkink LB , Siega-Riz AM . 10- Medical- Surgical- Nursing- Intensive- Review , Arbab-Zadeh A Systemic lupus erythematosus (SLE) is a multisystem autoimmune rheumatic disease (ARD) characterized by flares and remissions. , Gladman DD A high variability in scales was found, causing a wide range of reliability (intraclass correlation coefficient 0.670.98). Objective: The Physician Global Assessment (PGA) is a visual analogue score that reflects the clinician's judgement of overall SLE disease activity. Associations between physicians' global assessment of disease activity Fanouriakis A Compared with nonresponders, BICLA responders had greater improvements in global and organ-specific disease activity (Physician's Global Assessment, SLE Disease Activity Index 2000, Cutaneous Lupus Erythematosus Disease Area and Severity Index Activity, and joint counts; all nominal P < 0.001). , Ibaez D Laboratory Investigation Results Influence Physician's Global Feb 2016 - Jan 20182 years. et al. SLE3. Convergent validity is fulfilled indirectly in studies where the PGA is used as the gold standard to assess the construct validity of other indices. Help us improve CareerBuilder by providing feedback about this job: Report this job Job ID: 2281236908. et al. In one open-label study [43], the decrease in PGA score was considered the primary endpoint. Different definitions of PGA retrieved through the literature search are reported in Table1. , Gladman DD The Physician Global Assessment (PGA) of treatment response measures the overall response to treatment as assessed by the physician. This may be explored through convergent and divergent validity. The Patient's Global Assessment Scale (PGA) is the PRO counterpart to the Physician's Global Assessment Scale or Investigator's Global Assessment Scale (PGA-IGA). , Kalunian K An international panel of 79 SLE experts participated in a three-round Delphi consensus . Oxford University Press is a department of the University of Oxford. et al. Physician Global Assessment International Standardisation COnsensus in Systemic Lupus Erythematosus: the PISCOS study . JBT-101 in Systemic Lupus Erythematosus (SLE) To determine longitudinal associations between Physician Global Assessment (PGA) and patient-reported outcomes (PROs) in patients with systemic lupus erythematosus (SLE). , Aggarwal R Ragai Kiriakos, MD, MSc - Clinical Trials Physician - LinkedIn van Vollenhoven R , Beaumont JL Clinical Trial on Systemic Lupus Erythematosus (SLE): Blood sample , Landis RC Once two investigators (E.C., M.P.) The content can vary and relates either to global health (e . PGA-IGA described in ePROVIDE - Mapi Research Trust Barr et al. Barr SG In our centre, new tools for the assessment of SLE activity: the Lupus Activity Scoring Tool (LAST) and Clinical Lupus Activity Scoring Tool (C-LAST) were developed and validated. Additional papers were obtained by checking the references from the selected studies. , Askanase A et al. , Matos A Before All rights reserved. disease activity in SLE, with the Physician Global Assessment (PGA) being the only one included in the updated EULAR recommendations for the management of SLE.11. Psychometric properties data were analysed according to the OMERACT Filter methodology version 2.1. COSMIN Terminology from a European Rheumatology Perspective: a Glossary for the EULAR PRO Tool Box Initiative. , Mosca M The Physician Global Assessment (PGA) is a visual analogue score that reflects the clinician's judgement of overall SLE disease activity. et al. The assessment of disease activity in SLE is particularly challenging. AB - The Physician Global Assessment International Standardisation COnsensus in Systemic Lupus Erythematosus (PISCOS) study aimed to obtain an evidence . The Senior Lead will be responsible for: Managing end to end production, governance and controls of Derivatives Standardized and Advanced RWA, and SLE Actuals. Methods This SLR was conducted by two independent reviewers in accordance with the PRISMA statement. PMC Liang MH The literature search identified 91 studies. In this systematic review we have analysed the measurement properties of the PGA, including the validity, reliability, responsiveness and feasibility. OBJECTIVE The Physician Global Assessment (PGA) is a visual analogue score that reflects the clinician's judgement of overall SLE disease activity. , Su J , Kostopoulou M Parodis I This suggests that the role of the PGA is limited for disease activity assessment when used as a single instrument. , James JA All articles published through 1 July 2019 in PubMed were screened, with no limitation on year of publication, language or patients age. This potentially disfiguring disease can have significant impact on patient's quality of life (QoL) and is often refractory to many first- and second-line therapies. Reliability was excellent when scored through a pointed scale, such as the Likert scale, that was anchored in unit numbers from 0 (not active) to 7 (most active) (interRR ICC 0.96; intraRR ICC 0.88) [80], but was lower when assessed through a centimetric VAS using values between 0.0 and 3.0 (interRR ICC 0.67; intraRR ICC 0.55) [68]. Improving patient pathways for systemic lupus erythematosus: a multistakeholder pathway optimisation study. BICLA is a validated composite global measure of SLE disease activity including SLEDAI-2K, CLASI-A, OCS dosage reduction, and patient-reported outcomes. Measuring disease activity in adults with systemic lupus erythematosus Impact of anti-SARS-CoV-2 antibodies of different isotypes (IgA, IgG, IgM) on attainment of PGA . In the absence of a well-recognized gold standard for disease activity, criterion validity of the PGA is established when it correlates with a measure that the author of the study defined a priori as the gold standard. The sensitivity to change was estimated to be the smallest for the SLEDAI; the standardized response means were 0.48 when the physician global assessment was used as the standard and 0.01 when the patient global assessment was used . Epub 2014 Jul 10. et al. Vashisht P [8] suggested the need for a disease activity instrument that would be valid, reliable and sensitive to change. , Hearth-Holmes M. Khan A It does not provide a predefined or limited list of disease manifestations or organ systems, thus allowing one to capture all the heterogeneous aspects of SLE disease activity. Bethesda, MD 20894, Web Policies Keywords: They proposed a physician global score on a 10cm visual analogue scale (VAS) to be used as a gold standard to compare six disease activity instruments [4]. How does one assess and monitor patients with systemic lupus , Emamikia S et al. New Tools to Measure Disease Activity in SLE - Rheumatology Network . J Clin Med. Deconstruction of the safety of estrogen in lupus erythematosus national assessment-systemic lupus erythematosus disease activity index flare index. The PGA is intended to encapsulate the physician's judgement of overall disease activity.Consensus on whether the PGA should be performed prior to, or after the receipt of laboratory values is lacking. Navarra SV Measurement properties of the PGA were analysed according to the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) terminology [19]. , Buyon J To increase its reliability, the PGA should be scored by a physician with significant expertise in SLE, with prior knowledge of laboratory results [112], considering the overall disease activity at the time of the visit and comparing it to the last visit in order to assess flares [9]. , Morabito LM Higher disease activity is an important predictor of both organ damage and mortality [2] and the attainment of low disease activity is associated with a reduction in early damage [5, 6]. , Urowitz MB. Clipboard, Search History, and several other advanced features are temporarily unavailable. The Physician Global Assessment International Standardisation COnsensus in Systemic Lupus Erythematosus (PISCOS) study aimed to obtain an evidence-based and expert-based consensus standardisation of the Physician Global Assessment (PGA) scoring of disease activity in systemic lupus erythematosus (SLE). Fatigue is independently associated with disease activity assessed using the Physician Global Assessment but not the SLEDAI in patients with systemic lupus erythematosus. The Physician Global Assessment (PGA) is an important tool for assessing disease activity in lupus. (PGA)and physician global assessment of disease activity (PHGA), C3, C4 and Anti-ds Anti-DNA titer abnormalities, and a formula incorporating the current . , Karp DR Learn more. Objective Physician's global assessment (PGA) of disease activity is a major determinant of therapeutic decision making. , Ho LY , Magder L Tyk2 Targeting in Immune-Mediated Inflammatory Diseases Complement-Targeted Therapeutics Market Report (2022 to The site is secure. There is no cure for lupus, but medical . Use of Physician Global Assessment in systemic lupus erythematosus: a The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). , Magder LS These results enabled its use as a gold standard for assessing flare and defining flare severity in several studies [21, 67, 88]. Systemic Lupus Erythematosus (SLE) Treatment & Management - Medscape Objective: In only one study [4], was PGA sensitivity assessed comparing the change with an anchor [109], represented by the treatment sensitive index: PGA sensitivity was found to be between that of the BILAG (highest sensitivity) and the SLEDAI (lowest sensitivity). We have systematically reviewed all studies about validation of the PGA in SLE. Cloud, mobility, security, and more. In conclusion, the PGA was demonstrated to be a valid, responsive and feasible instrument, but its reliability was strongly impacted by the scale adopted, suggesting the need for standardization in its scoring. The aim of this systematic literature review is to describe and analyse the psychometric properties of the PGA. Prinsen CAC Results of a large, multicentric, nationwide study, American College of Rheumatology provisional criteria for global flares in childhood-onset systemic lupus erythematosus, A cross-sectional study of hydroxychloroquine concentrations and effects in people with systemic lupus erythematosus, Inactive disease and remission in childhood-onset systemic lupus erythematosus, Preliminary criteria for global flares in childhood-onset systemic lupus erythematosus, Systemic lupus erythematosus in a multiethnic US cohort, XXXVII: association of lymphopenia with clinical manifestations, serologic abnormalities, disease activity, and damage accrual, Systemic lupus erythematosus in a multiethnic cohort (LUMINA): XXIX. Global Respiratory Devices Market Size, Growth, Source Analysis, Top , Petri M. Isenberg DA 2022 Mar 14;24(1):70. doi: 10.1186/s13075-022-02756-3. et al. , Raeisi A Please enable it to take advantage of the complete set of features! Background/Purpose: The Physician Global Assessment (PGA) is a frequently-used outcome measure in Systemic Lupus Erythematosus (SLE). In a post-hoc analysis of phase 3 belimumab trials, improvements and no worsening in the PGA were greater among SRI responders vs SRI non-responders (P<0.001) [52]. doi: 10.1136/lupus-2022-000700. The pooled correlation coefficient (95% CI) is given both for the fixed effects model and the random effects model. Touma Z In Fatemi et al. 2022 Sep;8(2):e002395. SELENA SLEDAI4. In 16 studies the PGA was used as a mean to assess changes in disease activity after treatment [3, 12, 22, 29, 40, 42, 43, 52, 54, 56, 57, 80, 85, 87, 95, 98, 101]. Mokkink LB ATI Comprehensive Predictor Exam 2019 (180 Q & A, Verified and 100 At least 1 issue from each virtual tour. Introduction Physician global assessments of disease activity (medical doctor (MD) globals) are important outcomes. Medical Cannabis Use by Rheumatology Patients Following Recreational , Perneger T Reliability measures the reproducibility of the instrument: it refers to the degree of agreement between different observers (interrater) and in the same observer over time (intrarater). , Francis S 1 2. , Seaman AL Thousand Oaks. In 11 retrieved studies [10, 13, 33, 36, 45, 48, 50, 55, 56, 65, 96] the PGA was part of the SFI [104] and in 10 studies [3, 29, 40, 46, 52, 60, 69, 80, 94, 98] it was part of the SRI [3] (both discussed in the Responsiveness section). , Shea BJ Physician Global Assessment International Standardisation COnsensus in , Glassman DS Chaigne B Tel: 03 88 12 84 74; Fax: 03 88 12 82 90; E-mail: Measuring disease activity in adults with systemic lupus erythematosus: the challenges of administrative burden and responsiveness to patient concerns in clinical research, Patterns of disease activity in systemic lupus erythematosus, Novel evidence-based systemic lupus erythematosus responder index, Reliability and validity of six systems for the clinical assessment of disease activity in systemic lupus erythematosus, Failure to achieve lupus low disease activity state (LLDAS) six months after diagnosis is associated with early damage accrual in Caucasian patients with systemic lupus erythematosus, Treatment target in newly diagnosed systemic lupus erythematosus, 10 most important contemporary challenges in the management of SLE, Measurement of systemic lupus erythematosus activity in clinical research, Definition, incidence, and clinical description of flare in systemic lupus erythematosus.

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